Taskbar Unresponsive On Startup

You can attempt clean boot to solve the issue. First of all, check for the occurrence of the issue in safe mode. If the issue does not happen in safe mode, it would mean there is some issue among the installed apps.
Perform the following steps to clean boot.

1. Click on Start, type in msconfig and click on enter.

2. Under General tab, and choose Selective Start Up.

3. Uncheck Load System services.

4. Under Services tab, check Hide all Microsoft services.

5. Click on Disable All button, then click on OK.

6. Now click on Restart. See if the issue persists after restart.

If the issue does not recur, it would indicate some of the installed software is causing the issue.
You will now need to disable the softwares one by one to check if the issue gets solved.

Taskbar being unresponsive seems to be issue with operating system specific, let me put down solutions which are generic in your context as you have not mentioned operating system build of your Windows.

Operating system agnostic option for you will be to check the issue from the command prompt and then restore the desktop properly. You can do this by opening command prompt and then typing

sfc /scan now

This should start the scanning and shows the potential errors that you have with the operating system.

Some of the options to resolve these errors are as follows -

Solution 1 : Component Store Corruption: In this method we can restore the components of the desktop manager. In order to do this we have to follow the steps below.

1. When you logged into the unresponsive taskbar. Press Win Key on your keyboard + "X". This will open the admin menu.
2. Select the "Command Prompt (Admin)" option.
3. Type the following command into it.
Dism /Online /Cleanup-Image /RestoreHealth
4. Let the Dism restore the failed components.
5. It'll also show you how to resolve other issues with the instructions on command prompt.

Solution 2 : Switch Admin Accounts : Sometimes some of the components end up unusable for certain admin. And for that to be fixed you just have to create another user account. You can do this by going to safe mode and create user accoun there. Or you can create new user account by going through command prompt or powershell. To to this open Admin Menu and then go to Settings > Users. You can also make the new user admin and then use that respective account. Make sure to switch all the existing program and settings for the new admin or the user.

Here are few other scenarios which you need to check while resolving this error.

1. If you are on Windows 10 and cortana enabled, then disable the cortana, reboot and system.
2. If you have Dropbox taskbar sync enabled, then remove the dropbox from the startup and then stop the taskbar sync. Reboot.
3. If you have quicktime loading it's drivers during the startup then you have to remove it from startup loading items.
4. Disable SSDP Discovery Service because often it crashes the taskbar and system tray.
5. Disable Background Intelligent Transfer Service as that could affect the taskbar from loading during the startup.

These are some of the common solutions however do note that depending on operating system build your scenario for the taskbar loading may be different. So you have to address the issue accordingly.

Most of the users are facing this taskbar unresponsive issues nowadays. While operating the system it is getting too inconvenient to access the taskbar. Even sometime I have faced this taskbar freezing problem. I have restarted to cure this, because I don't know how to solve this bug at that time. Later I found the possible solution to get the cure. Find the ways to solve this issue.

1. Go to Control panel.
2. Search for Folder option.
3. Click the view tab.
4. Uncheck automatically search for network folders and printers.
5. Then navigate for My Network Places.
6. Search for Hide icons for networked UPnP devices.
7. Status needs to show, Show icons for networked UPnP devices.
8. Next you need to disable the background services.
9. Go to 'Run' command.
10. Type msconfig and enter it.
11. Select the service tab.
12. Uncheck Background intelligent Transfer Service for disabling background services.
13. Click OK.
14. In the same service tab, uncheck SSDP Discovery service.
15. In the same service tab, select Hide all Microsoft services and click disable all option.
16. Need to drop unused devices, printers, faxes and USB devices.
17. Delete un-used network sharing folders in the device.
18. Delete any mapped drivers in your system.
19. End the background running process which is not a part of the operating system.
20. Large Files with taking too much memory space is also harming the functionality . So kill them all in this process.